USBio Logo

C2548-84W4 Mouse Anti-CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5) (PE)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Conjugate
PE
Isotype
IgG1
Clone Number
7H113
Grade
Affinity Purified
Applications
FC FLISA WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
CD40 Antigen Ligand, Hyper IgM Syndrome, T-B cell Activating Molecule

Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients.

Functional Application: Antibody will block MLR, sgp39 induced human B cell proliferation and T cell dependent B cell differentiation.
Applications
Suitable for use in Flow Cytometry, FLISA and Western Blot. Other applications not tested.
Recommended Dilution Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
Immunogen
Human sgp39 fusion protein
Form
Supplied as a liquid in 50mM Sodium Phosphate pH 7.5, 500mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3.
Purity
Purified by Protein A affinity chromatography.
Specificity
Iimmunoprecipitates a CD154 (gp39) molecule of about 39kD.
References
1. D. Gray, et al, (1994) Seminars in Immunol 6: 303-310. |2. F. Pietravalle, et al, (1996) J Biol Chemistry 271: 5965-5967. |3. S.M.A. Lens, (1996) J Immunol 156: 507-514. |4. R.J. Noelle, (1996) Immunity 4: 415-419. |5. A. Desai-Mehta, et al, (1996) J Clin Invest 97: 2063-2073. |6. I.S. Grewal and R.A. Flavell, (1996) Immunol Today 17: 410-414. |7. K.M. Aagaard-Tillery and D.F. Jelinek, (1996) J Immunol 157 : 2769-2778.
USBio References
No references available
Conjugates
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
Contact Us

Visit our technical library or contact our support staff to answer your questions.

Telephone:
1-800-520-3011

Library | Contact

Distributors

For customers outside of the United States, please use one of our many distributors.

View Distributors

Payment Methods

We accept the following payment methods as well as pay-by-invoice.

MasterCard Visa PayPal
© 2023-2024 United States Biological - All Rights Reserved