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C7850-46 Anti-Complement component C8, Recombinant, Human, aa21-202, His-Tag (Complement component C8 gamma chain, C8G)

Specifications
References
Grade
Highly Purified
Accession #
AAI13625
Shipping Temp
Blue Ice
Storage Temp
-20°C

C8G, is one of three polypeptides (along with C8 alpha and C8 beta) that constitutes C8, a component of the complement system. C8 participates in the formation of Membrane Attack Complex (MAC). Patients with deficiency in C8 are vulnerable to certain bacteria infection. C8gamma is a secreted protein that is able to bind retinol and belongs to the lipocalin family and calycin superfamily. It is synthesised in the liver, monocytes and fibroblast and functions to clear pathogens from an infected host.

Source
Recombinant corresponding to aa21-202 from human C8G, fused to His-tag at N-terminal expressed in E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MQKPQRPRRP ASPISTIQPK ANFDAQQFAG TWLLVAVGSA CRFLQEQGHR AEATTLHVAP QGTAMAVSTF RKLDGICWQV RQLYGDTGVL GRFLLQARGA RGAVHVVVAE TDYQSFAVLY LERAGQLSVK LYARSLPVSD SVLSGFEQRV QEAHLTEDQI FYFPKYGFCE AADQFHVLDE VRR
Molecular Weight
~22.6kD (MALDI-TOF)
Biological Activity
Not determined
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥95% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol, 2mM DTT, 0.15M sodium chloride.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol, 2mM DTT, 0.15M sodium chloride.
Purity
≥95% (SDS-PAGE)
References
1. Chiswell B., et al. (2007) Biochim Biophys Acta. 1774(5):637-44. 2. Schreck SF., et al. (2000) Biochim Biophys Acta. 1482(1-2):199-208.
USBio References
No references available
Conjugates
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