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C8299-05-ML650 Rabbit Anti-CX3CR1 (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28) (MaxLight 650)

Specifications
References
Brand
MaxLight™
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P49238
Conjugate
MaxLight™650
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo Rt
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free
BSA Free

MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.

Human CX3CR1 is a 40.4kD seven transmembrane protein. CX3CR1, known also as fractalkine receptor, is the receptor for CX3CL1 and acts as a co-receptor with CD4 for the HIV-1 envelope protein. It is expressed in a variety of human tissues and mediates leukocyte adhesion and migration.
Applications
Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended Dilutions
Immunohistochemistry: Paraffin sections Optimal dilutions to be determined by the researcher.
Immunohistochemistry Positive Control
Human heart
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Peptide corresponding to aa2-21, DQFPESVTENFEYDDLAEAC, from human CX3CR1. The sequence difffers from mouse and rat CX3CR1 by 4aa.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
Purity
Purified by Immunoaffinity chromatography.
Specificity
Recognizes an epiptope within the N-terminal region (NT) of human CX3CR1. Species Crossreactivity: rat and mouse
References
1. Combadiere C., et al (1995) Cloning, chromosomal localization and RNA expression of a human beta chemokine receptor-like gene. DNA Cell Biol. 14:673-680. 2. Combadiere C., et al (1998) Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem. Biophy. Res. Commun. 253:728-732. 3. Combadiere C., et al (1998) Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J.Biol. Chem. 273:23799-804. 4. Raport C.J., et al (1995) The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 163:295-299.
USBio References
No references available
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