DC-associated C-type lectin-2 (Dectin-2) is a type II transmembrane protein that is a member of the C-type lectin superfamily. In mouse, dectin-2 is predominantly expressed on tissue macrophages and some dendritic cells. Significant expression of Dectin-2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2 but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin-2 has not been fully determined but studies suggest a possible role in immune-surveillance.

Suitable for use in Flow Cytometry, Immunohistochemistry, and Immunoprecipitation. Other applications not tested.

Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher.

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Dectin 2 (extracellular domain) Fc Fusion protein.

Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.

Purified by Protein G affinity chromatography from tissue culture supernatant.

Recognizes mouse Dectin 2. Does not stain brain microglia or meningeal macrophages.