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D3221-45B Rabbit Anti-DSC1, CT (Desmocollin-1, Desmosomal Glycoprotein 2/3, DG2/DG3, Cadherin Family Member 1, CDHF1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q08554
Isotype
IgG
Grade
Affinity Purified
Applications
E FC WB
Crossreactivity
Hu
Accession #
NP_077739.1
Shipping Temp
Blue Ice
Storage Temp
-20°C

DSC1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined.

Applications
Suitable for use in Indirect Flow Cytometry, ELISA and Western Blot. Other applications have not tested.
Recommended Dilution
Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 659-687 in the C-terminal region of human DSC1.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human DSC1.
References
1. Toulza,E., et.al., Genome Biol. 8(6), R107 (2007). 2. Descargues,P., et.al., J. Invest. Dermatol. 126(7), 1622-1632 (2006).
USBio References
No references available
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