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D9635-51D Goat Anti-DSCAM (Down Syndrome Cell Adhesion Molecule, CHD2)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Ca Hu Mo Rt
Accession #
NP_001380.2, NP_996770.1
Gene ID
1826, 13508, 171119
Shipping Temp
Blue Ice
Storage Temp
-20°C

The Dscam family of cell surface proteins mediates recognition events between neurons that play an essential role in the establishment of neural circuits in many organisms. Interneurons form synaptic connections with retinal ganglion cells in specific layers. Dscam and DscamL are expressed in different subsets of interneurons and ganglion cells. Interestingly, interneurons and ganglion cells that target to the same layer, express the same Dscam protein.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:16,000 Western Blot: 2-6ug/ml, human brain, cerebellum lysates on ~170kD bands Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-DSWDSAQRTKDVSPQ, from human DSCAM, at the internal region of the protein (NP_001380.2, NP_996770.1).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human DSCAM. Species sequence homology: Canine, mouse and rat.
References
1. Li W, Guan KL. The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. J Biol Chem. 2004 Jul 30;279(31):32824-31.
USBio References
No references available
Conjugates
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