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D9900-03D-ML550 Mouse Anti-Dynamin 2 (Dynamin-2, DNM2, DYN2, Dynamin II, Dynamin-II, DYNII, CMTDI1, CMTDIB, DI-CMTB) (Azide Free) (MaxLight 550)

Specifications
References
Brand
MaxLight™
Clone Type
Monoclonal
Host
Mouse
Source
Human
Conjugate
MaxLight™550
Isotype
IgG1,k
Clone Number
10C23
Grade
Purified
Applications
FLISA WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free

MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000.

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
Applications
Suitable for use in FLISA and Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 1:500-1:1000 FLISA: 1ug/ml-3ng/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Partial recombinant protein corresponding to a portion of amino acids within aa611-710 of human Dynamin 2 (AAH54501) with GST tag. MW of the GST tag alone is 26kD.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human Dynamin 2.
References
1. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064. Susman RD, et al. Neuromuscul Disord, 2010 Apr. PMID 20227276. HeikkilÀ O, et al. J Virol, 2010 Apr. PMID 20089652. Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset. Melberg A, et al. Neuromuscul Disord, 2010 Jan. PMID 19932619.
USBio References
No references available
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