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E3452-75B Anti-Erlotinib Hydrochloride, Free Base, EGFR Inhibitor (CP-358774, OSI-774, Ro 50-8231)

Specifications
References
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride; NSC 718781; CP-358774, OSI-774, Ro 50-8231

Erlotinib Hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.

Synonyms
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride; NSC 718781; CP-358774, OSI-774, Ro 50-8231
CAS No
183321-74-6
Molecular Formula
C22H23N3O4
Molecular Weight
393.44
Purity
≥95%
Appearance
White solid
Solubility
DMF: 50mg/ml DMF:PBS (pH 7.2) (1:9): 0.1mg/ml DMSO: 25mg/ml Ethanol: 0.25mg/ml
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Pollack, V.A., Savage, D.M., Baker, D.A., et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice. Journal of Pharmacology and Experimental Therapeutics 291, 739-748 (1999). 2. Greulich, H., Chen, T.H., Feng, W., et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2(11), (2005). 3. Yamasaki, F., Zhang, D., Bartholomeusz, C., et al. Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity. Mol. Cancer Ther. 6(8), 2168-2177 (2007). 4. Li, Z., Xu, M., Xing, S., et al. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J. Biol. Chem. 282(6), 3428-3432 (2007). 5. Herbst, R.S., and Bunn, P.A., Jr. Targeting the epidermal growth factor receptor in non-small cell lung cancer. Clin. Cancer Res. 9(16), 5813-5824 (2003). 6. Gerber, D.E. EGFR inhibition in the treatment of non-small cell lung cancer. Drug Dev. Res. 69(6), 359-372 (2008).
USBio References
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