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F0015-19 Mouse Anti-Factor VII (Coagulation Factor VII, F7, Eptacog alfa, Proconvertin, Serum Prothrombin Conversion Accelerator, SPCA)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P08709
Isotype
IgG1
Clone Number
RFF-VII/2
Grade
Affinity Purified
Applications
E RIA WB
Crossreactivity
Hu
Gene ID
2155
Shipping Temp
Blue Ice
Storage Temp
-20°C
Coagulation Factor VII (Serum Prothrombin Conversion Accelerator), EC=3.4.21.21

Factor VII is a serine protease found circulating in the blood. It initiates the extrinsic pathway of blood coagulation in conjunction with tissue factor. Tissue factor is found on the outside of blood vessels. When the vessels is damaged, tissue factor is exposed to the blood and circulating Factor VII. Once bound to tissue factor, Factor VII is activated by different proteases and converts Factor IX to IXa. Factor VII deficiency is a rare hereditary haemorrhagic disease. Symptoms range from mild to severe.

Applications
Suitable for use in ELISA, Western Blot and RIA. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Purified Factor VII
Form
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes human Factor VII. Binds to a conformational epitope and will not bind to reduced Factor VII.
References
1. Takase, T. et al. (1988) Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag. J. Clin. Pathol. 41: 337-341.
USBio References
No references available
Conjugates
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