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G8951-15N Rat Anti-Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sargramostim)

Specifications
References
Clone Type
Monoclonal
Host
Rat
Source
Human
Swiss Prot
P04141
Isotype
IgG2a,k
Clone Number
BVD2-23B6
Grade
Purified
Applications
E IP
Crossreactivity
Hu
Accession #
NP_034099
Shipping Temp
Blue Ice
Storage Temp
-20°C
Notes
Preservative Free

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages. It promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells.

Applications
Suitable for use in Immunoprecipitation and ELISA. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Matched Pair
Detection: 228209 Capture: G8951-15N
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
E. coli-expressed human GM-CSF
Form
Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.
Purity
Purified
Specificity
Recognizes human granulocyte/macrophage-colony stimulating factor. Species Crossreactivity: Rhesus and Cynomolgus monkey
References
1. Bacchetta, R., T. de Wall Malefyt, H. Yssel, J.S. Abrams, J.E. de Vries, H. Spits, and M.G. Roncarolo. 1990. J. Immunol. 144:902.|2. Kita, H., T. Ohnishi, Y. Okubo, D. Weller, J.S. Abrams, and G.J. Gleich. 1991. J. Exp. Med. 174:745.|3. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Immunol. Rev. 127:5.|4. Abrams, J., J. Silver, R. van Dyke, and G. Gleich. 1994. Eosinophil-active cytokines in human disease: Development and use of monoclonal antibodies to IL-3-, IL-5, GM-CSF. In Eosinophils in Allergy and Inflammation (A. Kay and G. Gleich, eds). Marcel Dekker, New York, pp. 133.
USBio References
No references available
Conjugates
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