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I8431-75D Mouse Anti-CD129 (Interleukin-9 Receptor, IL-9 Receptor, IL-9R, IL9R)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q01113
Isotype
IgG2b,k
Clone Number
AH9R7
Grade
Affinity Purified
Applications
E FC
Crossreactivity
Hu
Gene ID
3581
Shipping Temp
Blue Ice
Storage Temp
-20°C

CD129 serves as the high affinity alpha subunit of IL-9 receptor. It associates with CD132, the common gamma chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.

Applications
Suitable for use in ELISA and Flow Cytometry. Other applications not tested.
Recommended Dilution
Flow Cytometry: it is recommended to use bright fluorochromes or signal multiplying detection. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Human CD129-transfected cell line
Form
Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CD129.
References
1. De Smedt, M., et al. 2000. J. Immunol. 164:1761. 2. Pilette, C., et al. 2002. J. Immunol. 168:4103. 3. Demoulin, J. B., et al. 1996. Mol. Cell. Biol. 16(9):4710. 4. Demoulin, J. B., et al. 1996. Mol. Cell. Biol. 16:4710.
USBio References
No references available
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