jumonji-like protein, jumonji, AT rich interactive domain 2 protein, jumonji homolog, OTTHUMP00000016058, JMJ, jumonji, AT rich interactive domain 2, JARID2

This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein.