LTBR, also known as Lymphotoxin beta Receptor and tumor necrosis factor receptor superfamily member 3 is a 47kD transmembrane protein containing 3 TNF receptor domains. The LTBR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTa and LTB as well as light. LTBR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LTBR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LTBR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LTBR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. This antibody is an agonistic antibody for the LTBR capable of inducing apoptosis (with IFN-g treatment).