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M9875-02M Rat Anti-Myostatin/GDF8/GDF11 (MSTN, Growth Differentiation Factor 8, Growth/Differentiation Factor 8, Growth Differentiation Factor 11, BMP-11)

Specifications
Clone Type
Monoclonal
Host
Rat
Source
Mouse
Swiss Prot
O08689
Isotype
IgG2b
Clone Number
11C40
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

GDF­8, also known as Myostatin, belongs to the TGF-beta superfamily. It is synthesized as an inactive proprotein with the N­terminal pro­region and the C­terminal mature bioactive region. The GDF­8 proregion is capable of associating with active GDF­8 with high affinity and is a potent GDF­8 antagonist.

Applications
Suitable for use in Western Blot and Direct ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to Asn25-Ser376 of mouse GDF-8 expressed in NS0 cells. Swiss/UniProt: O08689.
Form
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
Purity
Purified by Protein G affinity chromatography from culture supernantant.
Specificity
Recognizes mouse, human and rat GDF8 in direct ELISA and WB. Shows ~30% cross-reactivity with recombinant human, mouse and rat GDF11 in WB. Shows <1% cross-reactivity with recombinant mouse GDF1, GDF3, GDF5, GDF6 and GDF9 in direct ELISA.
Conjugates
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