Nectin-1, also called PVRL1, PRR1, Vec C, CD111, HveC and HigR, is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic cells, neuronal cells, endothelial and epithelial cells. Nectin-1 belongs to a new family of immunoglobulin-like molecules that includes four members (Nectin-1, -2, -3 and CD155). Nectin-1 gene is localized to human chromosome 11q23-q24, and encodes at least two different transmembrane isoforms. Nectin-1 is a pan alpha herpes virus entry receptor that mediates entry of many HSV1 and HSV-2 strains, bovine Herpes virus1 (BHV-1) and porcine pseudorabies virus (PRV).