NY-ESO-1 is a member of the cancer/testis (CT) family of antigens. Cancer/testis antigens are expressed in a range of malignant neoplasmas such as melanoma and carcinomas of the breast, ovary and lung, but not in normal tissue except in testis. NY-ESO-1 is a classic CT antigen discovered during a SEREX analysis of esophageal cancer. It is a 22-23kD hydrophobic protein.
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