gVPLA2, Secretory Phospholipase A2 (human Group V)

Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family. This enzyme, rather than the sPLA2 (type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells. Consistent with this role, sPLA2 (type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells.6 sPLA2 (type V) has been cloned from a variety of species including human, mouse, and rat. The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells.