Type I plasminogen activator inhibitor, PAI 1, is a 50kD single- chain glycoprotein which belongs to the serine protease inhibitor (SERPIN) family of proteins. The concentration of PAI 1 in normal human plasma is very low, with an average concentration of ~20ng/ml. The plasma concentrations of PAI 1 can be affected by a number of factors including diurnal variations, age, sex, pregnancy, obesity and exercise status. PAI 1 is synthesized by various cell types including endothelial cells, hepatocytes, vascular smooth muscle cells, fibroblasts, mesothelial cells, granulosa cells and malignant cell lines. It is also found in the alpha-granules of platelets as well as plasma. PAI 1 exists in at least three different conformations, including an active form with a half-life of ~1-3 hours, a latent form and a proteolytically or oxidatively inactivated form. The plasma glycoprotein vitronectin has been shown to bind active PAI 1 and stabilize it in its active conformation, extending its functional half-life to greater than 24 hours. Little specific binding of the latent or inactive forms of PAI 1 to vitronectin occurs. PAI 1 is considered to be the primary regulator of plasminogen activation in vivo. It is the major physiologic inhibitor of both the single chain and two-chain forms of tPA, being able to inhibit the single-chain form at least 10000 times greater than other PAIs.
Product | Size | List | Your Price | Qty | Ext Price | ||||
---|---|---|---|---|---|---|---|---|---|
Subtotal: | Subtotal: | ||||||||
Subtotal: | Subtotal: | ||||||||
Total Coupon Savings: | Total Coupon Savings: | () | |||||||
Your cart is currently empty. | |||||||||
- Coupon Code |