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P5575-01B-ML550 Rabbit Anti-PR Set7 (SET8, SET Domain Containing 8, SET Domain-containing Protein 8, SET Domain Containing Lysine Methyltransferase 8, SET Domain-containing (Lysine Methyltransferase) 8, SETD8, H4 K20 Specific Histone Methyltransferase, H4-K20-HMTase SETD8, PR/SET Domain-containing Protein 07, PrSET7, Pr-SET7, PR/SET07, PR/SET Domain-containing Protein 8, SET07) (MaxLight 550)

Specifications
References
Brand
MaxLight™
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NQR1
Conjugate
MaxLight™550
Isotype
IgG
Grade
Affinity Purified
Applications
IC WB
Crossreactivity
Hu
Accession #
NP_065115.3
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free
BSA Free

MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000.

SETD8 (hPR-SET7) is a histone methyltransferase that adds a single methyl group to 'Lys-20' of histone H4. H4 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. SETD8 (hPR-SET7) is located in the nucleus and may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail.
Applications
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Positive Control
HeLa nuclear extract.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
GST-tagged recombinant protein corresponding to human SETD8 (hPR-SET7).
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SETD8. Species sequence homology: mouse, rat (100%).
References
1. Rice, J.C., et al., Genes Dev 16: 2225-2230, 2002. 2. Nishioka, K., et al., Mol. Cell. 9: 1201-1213, 2002.
USBio References
No references available
Conjugates
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