PP-2 C alpha/beta is heterodimer located in the mitochondrial matrix. Within the pyruvate dehydrogenase complex, PP-2 C alpha/beta serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit. Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.

Suitable for use in Western Blot. Other applications not tested.

Optimal dilutions to be determined by the researcher.

L6 Cell Lysate.

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Synthetic peptide corresponding to human Protein Phosphatase 2 C alpha/beta (KLH). Species Sequence homology: mouse and bovine.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550.

Purified by ammonium sulfate precipitation.

Recognizes the alpha/beta regulatory subunit isotype of human phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46kD protein. Species crossreactivity: rat.