PYK2 (Proline-rich kinase 2; also Ptk2b, Fak2, RAFTK and CAKb) is a 112-116kD member of the Fak subfamily, tyrosine protein kinase family. It is expressed in multiple cell types, including endothelial cells, vascular smooth muscle cells, megakaryocytes and neurons. PYK2 is activated by elevated intracellular Ca and is associated with MAPK pathway activation. Human PYK2 is 1009aa in length. PYK2 phosphorylation at Tyr402 is associated with enzymatic activation, intercellular localization, cell growth, cell motility, and regulating molecular ssociations. Over aa390-410, human PYK2 is 100% aa identical to mouse PYK2.
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