S100A7 is an 11-13kD member of the S101 family, EF-hand superfamily of Ca-binding proteins. It is produced by keratinocytes and exists as both an intracellular and extracellular polypeptide. Intercellularly, it binds to E/FABP and may participate in fatty acid metabolism. Extracellularly, it is both monomeric and heterooligomeric and exhibits antibacterial properties. Human S100A7 is 101aa in length. It contains two EF-hand motifs aa13-48, 50-85, three zinc-binding His residues, one high-affinity Ca-binding site aa63-74 and an overlapping antibacterial sequence aa35-80. There appear to be no meaningful rodent structural orthologs. Human S100A7 is 93aa identical to human S100A15/7A, and the S100A7 gene has a duplication (S100A7B) that is 54aa identical to S100A7.