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S1014-18U Rabbit Anti-SLITRK5 (SLIT and NTRK-like Family Member 1, HGNC:20297, KIAA0918, KIAA1910, Leucine-rich Repeat-containing Protein 12, LRRC12, RP11-395N17.1, Slit and trk-like 1 Protein, Slit and Trk-like Gene 1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
O94991
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

SLIT and NTRK-like family 5 (Slitrk5) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains (1). Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family (1,2). Like every other Slitrk protein except Slitrk1, overexpression of Slitrk5 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.

Applications
Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 0.5–1ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide corresponding to 14aa from near the center of human Slitrk5 (GenBank accession no. O94991).
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Slitrk5. Species crossreactivity: Mouse and rat.
References
1. Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci. 2003; 24:117-29. 2. Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene 2003; 315:87-94.
USBio References
No references available
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