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S1014-20U Mouse Anti-SLP 76 (SH2 Domain Containing Leukocyte Protein 76kD, SH2 Domain-containing Leukocyte Protein of 76kD, SH2 Domain Containing Leukocyte Protein of 76kDa, SLP76, SLP-76, SLP76 Tyrosine Phosphoprotein, SLP-76 Tyrosine Phosphoprotein, 76kD Tyrosine Phosphoprotein, Lymphocyte Cytosolic Protein 2, LCP2)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q13094
Isotype
IgG2b
Clone Number
SLP-76/03
Grade
Purified
Applications
IHC WB
Crossreactivity
Hu Mo Po
Shipping Temp
Blue Ice
Storage Temp
-20°C

SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Fusion protein representing aa216-434 of human SLP-76, fused to His-Tag, expressed in bacteria.
Form
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Purity
Purified
Specificity
Recognizes human SLP-76 (SH2 domain-containing leukocyte protein). Species Crossreactivity: mouse and porcine.
References
1. Pivniouk VI, et al. J Clin Invest. 1999 Jun; 103(12):1737-43.|2. Koretzky GA, et al. Nat Rev Immunol. 2006 Jan; 6(1):67-78.|3. Silverman MA, et al. Mol Cell Biol. 2006 Mar; 26(5):1826-38.|4. Beach D, et al. J Biol Chem. 2007 Feb 2; 282(5):2937-46
USBio References
No references available
Conjugates
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