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S1040-01E Rabbit Anti-SOCS 1(Suppressor of Cytokine Signalling 1, Janus kinase (JAK) binding protein, STAT-induced STAT inhibitor, SSI-1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C

SOCS-1, also called Janus kinase (JAK) binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is an SH2-domaincontaining protein. It was shown to interact with all four Jak kinases (Jak1, Jak2, Jak3 and Tyk2) and is induced by and inhibits the signaling action of IL-3, IL-4, IL-6, growth hormone, LIF, prolactin, interferon gamma (IFN-g), and erythropoietin. It plays an important role in the negative regulation of IFN-g signaling and in the differentiation of T-cells. SOCS-1 mRNA is highly expressed in the thymus, to a much lower level in spleen, and not expressed in most other tissues. Biochemical characterization as well as gene disruption studies indicate that SOCS-1 is an important negative regulator of the JAK-STAT signal pathway.

Applications
Suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilution
Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher.
Positive Controls
Mouse thymus cell lysates and HepG2 human hepatocellular carcinoma lysate.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
A synthetic peptide derived from the C-terminal region of human, mouse or rat SOCS-1 protein
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes the human SOCS-1 protein at ~30kD. Species Crossreactivity: mouse Species Sequence Homology: rat
References
1. Sporri B, et al. Blood 97: 221-226, 2001. 2. Krebs D.L., Hilton, D.J. J Cell Sci. 113: 2813-2819, 2000. Marine JC, et al. Cell 98: 609-616, 1999.
USBio References
No references available
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