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S5353-02N Goat Anti-SORL1 (Sortilin-related Receptor, Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats, LDLR Relative with 11 Ligand-binding Repeats, LR11, SorLA-1, Sorting Protein-related Receptor Containing LDLR Class A Repeats, SorLA, C11orf32)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Bo Ca Hu Mo Rt
Accession #
NP_003096.1
Gene ID
6653
Shipping Temp
Blue Ice
Storage Temp
-20°C

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:32,000 Western Blot: 0.3-1ug/ml, observed in mouse and rat brain lysates on ~250kD bands Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-TGFSDDVPMVIA, from mouse SORL1, at C-terminal (NP_003096.1).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse SORL1. Species sequence homology: Bovine, canine, human and rat.
References
1. Kim E, Lee Y, Lee HJ, Kim JS, Song BS, Huh JW, Lee SR, Kim SU, Kim SH, Hong Y, Shim I, Chang KT. Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem Biophys Res Commun. 2010 Dec 10;403(2):167-71.
USBio References
No references available
Conjugates
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