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S5364-11Q Rabbit Anti-SOX2 (Transcription Factor SOX-2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Ch Fe Hu Mo Po
Accession #
NP_003097.1
Shipping Temp
Blue Ice
Storage Temp
-20°C

SOX2, the basic helix-loop-helix transcription factor, is indispensable for maintaining embryonic stem (ES) cell pluripotency. The gene expresses in self-renewing progenitor cells and acts to inhibit neuronal differentiation. SOX2, along with other transcription factors Oct3/4, Klf4, and c-Myc are used to generate induced pluripotent stem cells from mouse fibroblasts by retrovirus mediated introduction. It is expressed throughout the human brain, including the developing hypothalamus, as well as the Rathke pouch, the developing anterior pituitary and the eye. It is necessary for the normal development of the hypothalamo-pituitary and reproductive axes in mice. Mutation of the SOX2 gene in progenitor cells leads to cerebral malformation, severe eye defects, and hypothalamo-pituitary abnormalities.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Mouse Embryo Brain
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa100-150 of human SOX2.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SOX2. Species Crossreactivity: feline, chicken, chimpanzee, mouse, porcine, rhesus monkey. Species sequence homology: opossum, rat.
References
1. Bylund, M. et al. Nature Neurosci. 6:1162-1168 (2003). 2. Kelberman, D. et al. J. Clin. Invest. 116:2442-2455 (2006). 3. Takahashi, K. Cell. 126:663-676 (2006). 4. Masui, S. et al. Nature Cell Biol. 9:625-635 (2007). 5. Kelberman, D. et al. J. Clin. Endocr. Metab. 93:1865-1873 (2008).
USBio References
No references available
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