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S7500-05 Goat Anti-Six-transmembrane epithelial antigen of the prostate-1 (STEAP1, six transmembrane epithelial antigen of the prostate 1, Metalloreductase STEAP1, MGC19484, PRSS24, Six-transmembrane epithelial antigen of prostate 1, STEAP)

Specifications
Clone Type
Polyclonal
Host
Goat
Source
Human
Swiss Prot
Q9UHE8
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

STEAP1 (six-transmembrane epithelial antigen of the prostate-1) is a 40kD protein (predicted) of the STEAP family of metalloreductases. It is expressed mainly at cell-cell junctions between prostate secretory epithelium, and upregulated in prostate and some bladder, colon and ovarian cancers and Ewing’s sarcomas. Human STEAP1 is 339aa in length. It contains a ferric oxidoreductase domain (aa119-265) that includes transmembrane sequences (# 2, 3, 4 and part of 5, out of 6 sequences). Two splice forms diverge at aa255, terminating after aa58 or 259. Over aa1- 71, human and mouse STEAP1 share 68% aa identity.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1ug/ml using LNCaP human prostate cancer cell line Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to Met1-His72 from human Six-transmembrane epithelial antigen of the prostate-1, expressed in E. coli
Form
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Six-transmembrane epithelial antigen of the prostate-1.
Conjugates
Pricing
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