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T1501-04C Goat Anti-TBC1D4 (TBC1 Domain Family Member 4, Akt Substrate of 160kD, AS160, KIAA0603)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Ca Hu
Accession #
NP_055647.2
Gene ID
9882
Shipping Temp
Blue Ice
Storage Temp
-20°C

TBC1D4 may act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of cell lines daudi and MOLT4 on ~150kD bands Immunohistochemistry (Paraffin): 3-5ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-DDPEKIEERKKSK, from human TBC1D4, at the internal region of the protein (NP_055647.2).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TBC1D4. Species sequence homology: Canine.
References
1. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun;54(6):1692-7.
USBio References
No references available
Conjugates
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