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003958 BIIB 021 CAS: 848695-25-0

Specifications
References
CAS Number
848695-25-0
Grade
Highly Purified
Molecular Formula
C14H15ClN6O
Molecular Weight
318.76
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-yl]amine;

BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.

References
Lundgren, K. et al.: Mol. Cancer Ther., 8, 921 (2009); Boell, B. et al.: Clin. Cancer Res., 15, 5108 (2009); Yin, X. et al.: Int. J. Cancer, 126, 1216 (2010);
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