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004547 Bosutinib CAS: 380843-75-4

Specifications
References
CAS Number
380843-75-4
Grade
Highly Purified
MDL Number
MFCD07367846
Molecular Formula
C26H29Cl2N5O3
Molecular Weight
530.45
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
SKI-606, 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile, WAY-173606

Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML). It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate.

Synonyms
SKI-606, 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile, WAY-173606
CAS No
380843-75-4
Form
Off-white to light brown
Purity
≥98% (HPLC)
Melting Point
131-134°C
Solubility
DMSO: ≥15mg/ml
Pfizer Compound
References
Bjorge, J., et al.: J. Biol. Chem., 275, 41439
USBio References
No references available
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