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013654 2-Hydroxyisoquinoline-1,3(2H,4H)-dione CAS: 6890-08-0

Specifications
References
CAS Number
6890-08-0
Grade
Highly Purified
Molecular Formula
C9H7NO3
Molecular Weight
177.16
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
2-Hydroxy-1,3(2H,4H)-isoquinolinedione;

2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. It was investigated its interaction with Mg2+ and Mn2+ using different spectroscopic techniques and report that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.

Form
Brown Solid
Melting Point
197-200°C
Solubility
DMSO
References
Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),
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