Semagacestat CAS 425386-60-3

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020894 Semagacestat CAS: 425386-60-3

Specifications

References

CAS Number

425386-60-3

Grade

Highly Purified

Molecular Formula

C19H27N3O4

Molecular Weight

361.44

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide; LY 450139;

Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD).

Form

White Solid

Melting Point

214-216°C

Solubility

DMSO, Methanol

References

Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010); Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009); Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011);