ARHGAP10, ID CAS

Swiss Prot

Q08DP6

Grade

Affinity Purified

Gene ID

79658

Gene #

ARHGAP10

Accession Number

NP_078881.3; A1A4S6

EU Commodity Code

30021010

Shipping Temp

Blue Ice

Storage Temp

-20°C

ARHGAP10, GRAF2, Rho GTPase-activating protein 10, GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, Rho-type GTPase-activating protein 10

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Applications

Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry and ELISA. Other applications not tested.

Recommended Dilutions

Western Blot: 1:1000 Immunohistochemistry (Paraffin): 1:50-1:100 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

References

1. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 2. Azzato, E.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(4):1140-1143(2010). 3. Lind, P.A., et al. Twin Res Hum Genet 13(1):10-29(2010). 4. Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010). 5. Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)

USBio References

No references available

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032035 ARHGAP10, ID (ARHGAP10, GRAF2, Rho GTPase-activating protein 10, GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, Rho-type GTPase-activating protein 10) CAS:

Swiss Prot

Grade

Gene ID

Gene #

Accession Number

EU Commodity Code

Shipping Temp

Storage Temp

ARHGAP10, GRAF2, Rho GTPase-activating protein 10, GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, Rho-type GTPase-activating protein 10

References

USBio References

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