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045049 MTEP CAS: 329205-68-7

Specifications
References
CAS Number
329205-68-7
Grade
Highly Purified
Molecular Formula
C₁₁H₉ClN₂S
Molecular Weight
200.3
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
3-pyridine

Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces anti-parkinsonian-like effects in rats.

Synonyms
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
CAS No
329205-68-7
Molecular Weight
200.3
Molecular Formula
C₁₁H₉ClN₂S
Solubility
DMSO, 100% ethanol, methanol
Method for Determining Identity
Proton NMR
Appearance
Supplied as a light yellow solid.
Purity
≥98% (NMR)
Storage and Stability
Store at 4°C. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. 3--pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003)|2. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004) |3. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006) |4. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005) |5. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005) |6. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005)
USBio References
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