USBio Logo
Subscribe to our newsletter!

REGISTER | SIGN IN

Welcome | LOG OUT

045318 Streptozotocin CAS: 18883-66-4

Specifications
References
CAS Number
18883-66-4
Grade
Highly Purified
MDL Number
MFCD00006607
Molecular Formula
C₈H₁₅N₃O₇
Molecular Weight
265.2
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose; D-2-Deoxy-2-(3-methyl-3-nitrosoureido)glucopyranose; Estreptozocin; NSC 37917; NSC 85998; STRZ; STZ; Streptozocin; Streptozoticin; U 9889; Zanosar

Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic. Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter. O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) inhibitor. Genotoxic. Induces DNA damage. Produces DNA strand breaks. Cell death inducer. Antineoplastic. Anti-cancer agent used in chemotherapy. Induces cell cylce arrest at G2.

Synonyms
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; Streptozocin; STZ; NSC 85998; Antibiotic U9889; Zanosar
CAS Number
18883-66-4
Molecular Weight
265.2
Molecular Formula
C₈H₁₅N₃O₇
Solubility
Water or ethanol.
Method for Determining Identity
UV and IR
Appearance
Supplied as an off-white to pale yellow powder.
Purity
≥98% (HPLC) ≥75% (α anomer)
Note
Once the compound is in solution it spontaneously releases NO gas at room temperature. We recommend to prepare fresh solutions immediately before use.
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
References
●Streptozotocin, a new antibacterial antibiotic: J.J. Vavra, et al.; Antibiot. Ann. 7, 230 (1959)|●Studies on the diabetogenic action of Streptozotocin: N. Raketien, et al.; Cancer Chemother. Rep. 29, 91 (1963)|●Mutagenic activity of Streptozotocin: S.M. Kolbye & M.S. Legator; Mutat. Res. 6, 387 (1968)|●Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981)|●Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes: G.L. Wilson & E.H. Leiter; Curr. Top. Microbiol. Immunol. 156, 27 (1990) (Review)|●Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994)|●STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells: W.J. Schnedl, et al.; Diabetes 43, 1326 (1994)|●Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death: K. Liu, et al.; PNAS 97, 2820 (2000)|●Chromosomal response of human lymphocytes to Streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 503, 63 (2002)|●Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002) (Review)|●Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification: A.D. Bolzan & M.S. Bianchi; J. Environ. Pathol. Toxicol. Oncol. 22, 281 (2003)|●Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007)|●The mechanisms of alloxan- and streptozotocin-induced diabetes: S. Lenzen; Diabetologia 51, 216 (2008)|●Mechanisms of toxic effect of streptozotocin on beta-cells in the islets of langerhans: V.B. Pisarev, et al.; Bull. Exp. Biol. Med. 148, 937 (2009)|●The role of programmed cell death in streptozotocin-induced early diabetic nephropathy: W.H. Wu, et al.; J. Endocrinol. Invest. 34, e296 (2011)
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
Special Offers
20% OFF New Lab Discount Setting up a New Lab?
Apply for our New Lab Discount!
*Receive a 25% off LIST price coupon code via email.
Society Member Discount Members of the GSA, FASEB, ACS and SFN get even bigger discounts!
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Site Map

    ANTIBODIES

    BIOCHEMICALS

    BIOLOGICALS

    CULTURE MEDIA

    MOLECULAR BIOLOGY

    KITS AND ASSAYS

    Technical Resources

    BIO DICTIONARY

    CITEAB

    ENTREZ GENE

    GENBANK

    HISTOLOGY GUIDE

    NCBI

    OMIM

    PROTEIN RESOURCES

    PROTOCOLS

    PUBMED

    UNIPROT

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved