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207042 Alternariol Monomethyl Ether (9-O-Methylalternariol, Djalonensone, AME, BRN 0253553, 3,7-Dihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one) CAS: 26894-49-5

Specifications
References
CAS Number
26894-49-5
Grade
Highly Purified
Molecular Formula
C15H12O5
Molecular Weight
272.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Mycotoxin. Antifungal. Phytotoxic. Shown to possess DNA strand-breaking activity. Inhibits the activity of topoisomerase IIalpha (Topo IIalpha) in mammalian cells.

Synonyms
9-O-Methylalternariol; Djalonensone; AME; BRN 0253553; 3,7-Dihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one
CAS Number
26894-49-5
Source
Alternaria sp.
Formula
C15H12O5
Method for Determining Identity
Proton NMR
Solubility
Methanol, dichloromethane or methylene chloride
Molecular Weight
~272.3
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Alternaria sp.
Purity
≥98% (HPLC)
Form
Supplied as an off-white to light brown solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternariatenuis: H. Raistrick, et al.; Biochem. J. 55: 421 (1953). 2. Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soder- hall, et al.; Appl. Environ. Microbiol. 36: 655 (1978) 3. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin & F.S. Chu; Appl. Environ. Microbiol. 46: 1420 (1983). 4. Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis & M.E. Stack; Appl. Environ. Microbiol. 60: 3901 (1994). 5. Analysis of alternariol and alternariol monomethyl ether on flavedo and albedo tissues of tangerines (Citrus reticulata) with symptoms of alternaria brown spot.: R. F. Magnani, et al; J. Agric. Food Chem. 55: 4980 (2007) 6. Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51: 307 (2007). 7. Alternariol acts as a topoisomerase poison preferentially affecting the IIallpha isoform.: M. Fehr, et al.; Mol. Nutr. Food Res. 53: 441 (2009)
USBio References
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