USBio Logo

207429 Tropodithietic acid (TDA) CAS: 750590-18-2

Specifications
References
CAS Number
750590-18-2
Grade
Highly Purified
Molecular Formula
C8H4O3S2
Molecular Weight
212.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. Isomeric to thiotropocin. Antibacterial. Active against Gram-positive and Gram-negative bacteria. Antifungal and anti-nematodical. Shows antitumor activity. Bacterial signal substance.

CAS Number
750590-18-2
Source
Roseobacter gallaeciensis
Formula
C8H4O3S2
Solubility
DMSO, methanol or acetone
Molecular Weight
~212.3
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Roseobacter gallaeciensis
Purity
≥98% (HPLC)
Concentration
Not determined
Form
Supplied as an orange solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Thiotropocin, a new sulfur-containing 7-membered-ring antibiotic produced by a Pseudomonas sp.: K. Kin- taka, et al.; J. Antibiot. 37: 1294 (1984). 2. Thiotropocin biosynthesis. Shikimate origin of a sulfur-containing tropolone derivative: D.E. Cane, et al.; JACS 114: 8479 (1992). 3. Investigation of secondary metabolites of North Sea bacteria: fermentation, isolation, structure elucidation and bioactivity: L. Liang; Dissertation Univ. Göttingen page 1-136 (2003) [TDA isolation, spectral data, cryst. Structure]. 4. Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates: T. Brinkhoff, et al.; Appl. Environ. Microbiol. 70: 2560 (2004). 5. Ecology, inhibitory activity, and morphogenesis of a marine antagonsistic bacterium belonging to the Roseobacterclade: J.B. Bruhn, et al.; Appl. Environ. Microbiol. 71: 7263 (2005). 6. Computational studies of the tropone natural products, thiotropocin, tropodithietic acid, and troposulfenin. Significance of thiocarbonyl-enol tautomerism: E.M. Greer, et al.; J. Org. Chem. 73: 280 (2008). 7. Genetic dissection of tropodithietic acid biosynthesis by marine Roseobacters: H. Geng, et al.; Appl. Environ. Microbiol. 74: 1535 (2008). 8. Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade: V. Thiel, et al.; Org. Biomol. Chem. 8: 234 (2010). 9. The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis: M.R. Seyedsayamdost, et al.; Nat. Chem. 3: 331 (2011). 10. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select: C. H. Porsby, et al.; Antimicrob. Agents Chemother. 55: 1332 (2011). 11. Tropodithietic acid production in Phaeobacter gallaeciensis is regulated by N-acylhomoserinelactone-mediated quorum sensing: M. Berger, et al.; J. Bacteriol. 193: 6576 (2011) 12. Genetic analysis of the upper phenylacetate catabolic pathway in the production of tropodithietic acid by Phaeobacter gallaeciensis: M. Berger, et al.; Appl. Environ. Microbiol. 78: 3539 (2012). 13. A novel inducer of Roseobacter motility is also a disruptor of algal symbiosis: P. Sule & R. Belas; J. Bacteriol. 195: 637 (2013)
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved