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217221 BINA (Biphenyl-indanone A) CAS: 866823-73-6

Specifications
References
CAS Number
866823-73-6
Grade
Highly Purified
Molecular Formula
C30H30O4
Molecular Weight
454.56
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

A selective positive allosteric modulator for mGlu receptor subtype 2 (EC50 = 33.2nM in CHO cells expressing human mGlu2). No effect on other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

CAS Number
866823-73-6
Formula
C₃₀H₃₀O₄
Solubility
DMSO
Primary Target
mGlu2
Molar Mass
454.56
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
≥98% (HPLC)
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Bonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett. 15, 4354.|2. Galici, R., et al. 2006. J. Pharmacol. Exp. Ther. 318, 173.|3. Benneyworth, M., et al. 2007. Mol. Pharmacol. 72, 477.|4. Sheffler, D., et al. 2011. ACS Chem. Neurosci. 2, 382.
USBio References
No references available
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