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256002 NKH 477 CAS: 138605-00-2

Specifications
References
CAS Number
138605-00-2
Grade
Highly Purified
Molecular Formula
C₂₇H₄₄ClNO₈
Molecular Weight
546.09
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
N,N-Dimethyl-β-alanine (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl Ester HCl; |N,N-Dimethyl-β-alanine [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl Ester HCl; |1H-Naphtho[2,1-b]pyran, β-alanine deriv.; 6-(3-Dimethylaminopropionyl)forskolin HCl; Adehl; Colforsin Dapropate HCl

NKH 477 is a water-soluble analog of Forskolin, that is a potent activator of adenylyl cyclase, which shows some selectivity for cardiac (type V) adenylyl cyclase).

Synonyms
N,N-Dimethyl-β-alanine (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl Ester HCl; N,N-Dimethyl-β-alanine [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl Ester HCl; 1H-Naphtho[2,1-b]pyran, β-alanine deriv.; 6-(3-Dimethylaminopropionyl)forskolin HCl; Adehl; Colforsin Dapropate HCl
CAS Number
138605-00-2
Molecular Formula
C₂₇H₄₄ClNO₈
Molecular Weight
546.09
Appearance
White to off-white solid
Purity
≥95%
Solubility
40mM in water
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Hirasawa, A. et al.: J. Cardiovasc. Pharmacol., 22, 847 (1993)|Ito, S. et al.: Brit. J. Pharmacol., 110, 1117 (1993|Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.|Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.|Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.|Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.|Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.|Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.|Shafiq, J., et al. 1992. Circ. Res. 71, 70.|Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
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