Prostaglandin E2 CAS 363-24-6

CAS Number

363-24-6

Grade

Highly Purified

Molecular Formula

C₂₀H₃₂O₅

Molecular Weight

352.47

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; PGE2; Prepidil

The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient. Inhibits NLRP3 by acting through receptor EP4 activation that increases cAMP and phosphorylates NLRP3 at serine 295 through PKA. PKA phosphorylation of NLRP3 inhibits the NLRP3 ATPase activity, which is required for assembly of NLRP3-ASC complexes.

A metabolite of arachidonic acid, synthesised by COX enzymes and prostaglandin E synthases (PGEs). Binds to EP1, EP2, EP3 and EP4 receptors with high affinity (Kd < 10 nM). Therapeutic potential for analgesia, pain relief and arthritic diseases. Enhances differentiation and expansion of iPSC-derived hematopoietic progenitor cells

Synonyms

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; PGE2; Prepidil

CAS No

363-24-6

Molecular Formula

C₂₀H₃₂O₅

Molecular Weight

352.47

Purity

≥98% (HPLC)

Appearance

White to off-white crystalline powder

Melting Point

66-68°C (lit)

Storage and Stability

Store at -20ºC. Stable for 6 months after receipt.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Coleman et al (1994). International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews, 46(2):205-29. 2. Park et al (2006). Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Journal of Clinical Immunology. 119(3):229-40. 3. Gori et al (2012). Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood, 120(13):e35-44. 4. Van Dorp, D.A., et al.: Biochem. Biopphys. Acta, 90:204 (1964) 5. Hamberg, M., et al.: J. Biol. Chem., 246:6713 (1971)

USBio References

No references available

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273128 Prostaglandin E2 (Dinoprostone) CAS: 363-24-6

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; PGE2; Prepidil

References

USBio References

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