2-Methoxy-N,N,β-trimethyl-10H-phenothiazine-10-propanamine Hydrochloride; 10-[3-(Dimethylamino) -2-methylpropyl]-2-methoxyphenothiazine MonoHydrochloride; 2-Methoxytrimeprazine Hydrochloride; 2-Methoxytrimeprazine
Racemic methotrimeprazine hydrochloride is a promazine derivative and an anti-psychotic drug. It is used in the treatment of schizophrenia, bipolar disorder and major depressive disorder. Metoprimeprazine increases the release of dopamine, serotonin, and norepinephrine in the brain. This drug also has a vasoconstrictor effect on small blood vessels, which can result in lowering blood pressure. Racemic methotrimeprazine hydrochloride is metabolized by cytochrome P450 enzymes to form its active form, which binds to the dopamine receptor.
Synonyms
2-Methoxy-N,N,β-trimethyl-10H-phenothiazine-10-propanamine Hydrochloride; 10-[3-(Dimethylamino) -2-methylpropyl]-2-methoxyphenothiazine MonoHydrochloride; 2-Methoxytrimeprazine Hydrochloride; 2-Methoxytrimeprazine
CAS No
4185-80-2 Free base: 851-68-3
Molecular Formula
C19H25ClN2OS
Appearance
Beige to dark beige solid
NMR, MS
Conforms to reference
Elemental Analysis
%C: 60.19, %H: 7.07, %N: 7.34
Water
~3.8% based on Elemental Analysis
Specific Rotation
+0.1° (c = 0.8, Methanol)
Solubility
DSMO (Slightly), Methanol (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
TDS
NCBI
UniProt
Tech Support
Customer Service
