CAS 856925-71-8

CAS Number

856925-71-8

Grade

Highly Purified

MDL Number

MFCD08460907

Molecular Formula

C18H16N2O2

Molecular Weight

292.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one, (S)-(-)-Blebbistatin

Synonyms

(S)-(-)-Blebbistatin

Chemical Name

1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one

Molecular Formula

C18 H16 N2O2

Molecular Weight

292.3

CAS Number

856925-71-8

Purity: ≥98%

Applications

Appearance

Crystalline solid

Storage: Product should be kept at -20°C.

Description

(-)-Blebbistatin is an Active enantiomer that selectively inhibits non-muscle myosin II ATPase activity and inhibits of smooth muscle myosin to a much lesser degree. Its effects can be inactivated by UV light and it is capable of rapidly and reversibly blocking cell blebbing by altering the forces that impinge on the cytoskeleton-membrane interface.

Storage

Soluble in organic solvents such as DMF or DMSO.

Purity

Highly Purified (~98%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Kovcs, M., Tth, J., Hetnyi, C., Mlnsi-Csizmadia, A., Sellers, J. R. (2004). Mechanism of blebbistatin inhibition of myosin II.Journal of Biological Chemistry, 279(34), 35557-35563. 2. Allingham, J. S., Smith, R., Rayment, I. (2005). The structural basis of blebbistatin inhibition and specificity for myosin II.Nature structural molecular biology, 12(4), 378-379. 3. Kolega, J. (2004). Phototoxicity and photoinactivation of blebbistatin in UV and visible light.Biochemical and biophysical research communications, 320(3), 1020-1025.

USBio References

No references available

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366870 (-)-Blebbistatin CAS: 856925-71-8

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Molecular Formula

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1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one, (S)-(-)-Blebbistatin

References

USBio References

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