Filipin III CAS 480-49-9

CAS Number

480-49-9

Grade

Purified

MDL Number

MFCD00466923

Molecular Formula

C35H58O11

Molecular Weight

654.8

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

Synonyms

Filimirasin, Filmirisin

Chemical Name

(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl -1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

Molecular Formula

C35 H58 O11

Molecular Weight

654.8

CAS Number: 480-49-9

Purity

≥85%

Applications

Appearance: Crystalline solid

Description

Filipin III is the most prevalent isomer of the Filipin complex, a potent polyene macrolide antibiotic and antifungal mixture. It is reported that it functions by disrupting the cell membrane. Filipin is also used as a histochemical stain for cholesterol as it is highly fluorescent and to inhibit the raft/caveolae endocytosis pathway in mammalian cells.

Storage

Soluble in organic solvents such as ethanol and DMSO.

Purity

Purified (~85%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Bittman, R., & Fischkoff, S. A. (1972). Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, and lagosin to cholesterol. Proceedings of the National Academy of Sciences, 69(12), 3795-3799. 2. Pandey, R. G., & RINEHART, K. L. (1970). POLYENE ANTIBIOTICS. V. CHARACTERIZATION OF COMPONENTS OF THE FILIPIN COMPLEX BY MASS SPECTROMETRY 1). The Journal of antibiotics, 23(8), 414-417. 3. Orlandi, P. A., & Fishman, P. H. (1998). Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. The Journal of cell biology, 141(4), 905-915.

USBio References

No references available

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366882 Filipin III (Filimirasin, Filmirisin) CAS: 480-49-9

CAS Number

Grade

MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

References

USBio References

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