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366900 MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886) CAS: 118427-55-7

Specifications
References
CAS Number
118427-55-7
Grade
Highly Purified
MDL Number
MFCD11045945
Molecular Formula
C27H33ClNO2S Na
Molecular Weight
494.1
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate

Synonyms
3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886,
Chemical Name
Sodium 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate
Molecular Formula
C27 H33 ClNO 2
Molecular Weight
494.1
CAS Number
118427-55-7
Purity
≥99%
Applications
FA
Appearance: Crystalline solid
Description
MK 886 is a potent and specific leukotriene biosynthesis inhibitor. It accomplishes this by blocking the FLAP protein and inhibiting 5-LOX. It is reported that MK 886 induces antiproliferative effects and apoptosis in HL-60 cells.
Storage
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 20mg/ml.
Purity
Highly Purified (~99%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Gillard, J., Ford-Hutchinson, A. W., Chan, C., Charleson, S., Denis, D., Foster, A., Pacholok, S. (1989). L-663,536 (MK-886)(3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Canadian journal of physiology and pharmacology, 67(5), 456-464. 2. Khan, M. A., Hoffbrand, A. V., Mehta, A., Wright, F., Tahami, F., Wickremasinghe, R. G. (1993). MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells. Leukemia research,17(9), 759-762. 3. Dittmann, K. H., Mayer, C., Rodemann, H. P., Petrides, P. E., Denzlinger, C. (1998). MK-886, a leukotriene biosynthesis inhibitor, induces antiproliferative effects and apoptosis in HL-60 cells. Leukemia research, 22(1), 49-53.
USBio References
No references available
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