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445828 DCPIB CAS: 82749-70-0

Specifications
References
CAS Number
82749-70-0
Grade
Highly Purified
Molecular Formula
C22H28Cl2O4
Molecular Weight
427.36
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic Acid

DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.

Synonyms
4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic Acid
CAS No
82749-70-0
Molecular Formula
C22H28Cl2O4
Molecular Weight
427.36
Purity (TLC)
≥98%
Appearance
White to off-white powder
Solubility
DMF, DMSO, Ethanol Make aqueous solutions daily.
Storage and Stability
Store at -20°C under inert atmosphere. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Decher, N., Lang, H.J., Nilius, B., et al. DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br. J. Pharmacol. 134(7):1467-1479 (2001). 2. Qiu, Z., Dubin, A.E., Mathur, J., et al. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell 157(2):447-458 (2014). 3. Lahey, L.J., Mardjuki, R.E., Wen, X., et al. LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol. Cell. 80(4),:578-591 (2020).|4. Lv, J., Liang, Y., Zhang, S., et al. DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chem. Neurosci. 10(6):2786-2793 (2019). 5. Zhang, Y., Zhang, H., Feustel, P.J., et al. DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra. Exp. Neurol. 210(2):514-520 (2008). 5. Bourke, R., et al.: J. Neurosurg, 55:364 (1981)
USBio References
No references available
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