4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone-|13C1,d2; (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-|pyrimidinone-13C1,d2; (-)-2’-Deoxy-3’-thiacytidine-13C1,d2; (-)-BCH 189-13C1,d2; 3TC-13C1,d2; Epivir HBV-13C1,d2; Hepitec-13C1,d2; Heptodin-13C1,d2; Heptovir-13C1,d2; L-SddC-13C1,d2; Lamivir-13C1,d2; Virolam-13C1,d2; Zeffix-13C1,d2; β-L-2’,3’-Dideoxy-3’-thiacytidine-13C1,d2; β-L-3’-Thia-2’,3’-dideoxycytidine-13C1,d2
Lamivudine-13C1,d2, is the labeled analogue of Lamivudine. A reverse transcriptase inhibitor. Antiviral.
Synonyms
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone- 13C1,d2; (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)- pyrimidinone-13C1,d2; (-)-2’-Deoxy-3’-thiacytidine-13C1,d2; (-)-BCH 189-13C1,d2; 3TC-13C1,d2; Epivir HBV-13C1,d2; Hepitec-13C1,d2; Heptodin-13C1,d2; Heptovir-13C1,d2; L-SddC-13C1,d2; Lamivir-13C1,d2; Virolam-13C1,d2; Zeffix-13C1,d2; β-L-2’,3’-Dideoxy-3’-thiacytidine-13C1,d2; β-L-3’-Thia-2’,3’-dideoxycytidine-13C1,d2
Molecular Formula
C713CH9D2N3O3S
Purity
Chemical Purity: ≥95% Isotopic Purity: ≥98%
Solubility
DMSO (slightly), Methanol (very slightly)
Melting Point
>118°C (dec.)
Specific Rotation
-127.5° (c=1; Methanol)
Method for Determining Identity
Proton NMR (DMSO-d6), C-13 NMR (DMSO-d6) and MS
TLC Conditions
SiO2; Dichloromethane : Methanol (8 : 2). Visualized with UV and KMnO4 (single spot; Rf = 0.35).
Storage and Stability
Store at -20°C under inert atmosphere. Caution: Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
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