BCMA CAS

Swiss Prot

O88472

Grade

Affinity Purified

EU Commodity Code

30021010

Shipping Temp

Blue Ice

Storage Temp

-20°C

Notes

Preservative Free
BSA Free

MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000.

BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184aa type I transmembrane protein, which contains a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa extracellular domain.

Applications

Suitable for use in Immunoprecipitation, Flow Cytometry, Western Blot and Functional Applications. Other applications not tested.

Recommended Dilutions

Functional Application: Blocks binding of BAFF to mouse BCMA. Optimal dilutions to be determined by the researcher.

Storage and Stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

References

1. S. Shulga-Morskaya, et al.; J. Immunol. 173, 2331 (2004) 2.E. Castigli, et al.; J. Exp. Med. 201, 35 (2005) Abstract. 3. APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis: G. Hardenberg, et al.; J. Leukoc. Biol. 84, 380 (2008)

USBio References

No references available

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B0807-52-ML550 BCMA (B Cell Maturation Protein) (MaxLight 550) CAS:

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