cAMP CAS 60-92-4

CAS Number

60-92-4

Grade

Highly Purified

MDL Number

MFCD00005845

Molecular Formula

C10H12N5O6P

Molecular Weight

329.23

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

Cyclic AMP-3',5'; Adenosine-3':5'-cyclic monophosphoric acid; Adenosine 3',5'-cyclophosphoric acid

Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is derived from adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway.

CcAMP is synthesized from ATP by adenylyl cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell.[1] Adenylyl Cyclase is activated by a range of signaling molecules through the activation of adenylyl cyclase stimulatory G (Gs)-protein-coupled receptors and inhibited by agonists of adenylyl cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylyl cyclase responds more strongly to glucagon, and muscle adenylyl cyclase responds more strongly to adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.

cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.

Purity

≥ 99%

Form

White, crystalline powder

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

No references available

USBio References

1. Rahman N, Buck J, Levin LR. pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC) Front Physiol. 2013 Nov 25;4:343. eCollection 2013. Review. PMID 4324443|2. GeneGlobe -> GHRH Signaling Retrieved on May 31, 2009|3. American Association for Cancer Research (cAMP-responsive Genes and Tumor Progression)|4. American Association for Cancer Research (cAMP Dysregulation and Melonoma)|5. American Association for Cancer Research (cAMP-binding Proteins' Presence in Tumors)|6. ScienceDaily::Brain Networks Strengthened By Closing Ion Channels, Research Could Lead To ADHD Treatment

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C8450-02 cAMP (Cyclic Adenosine Monophosphate, Cyclic AMP, Adenosine 3'5'-cyclic Monophosphate) 99+% (HPLC) CAS: 60-92-4

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Cyclic AMP-3',5'; Adenosine-3':5'-cyclic monophosphoric acid; Adenosine 3',5'-cyclophosphoric acid

References

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