Insulin-like Growth Factor Binding Protein 7 CAS

Brand

MaxLight™

Swiss Prot

Q16270

Grade

Affinity Purified

EU Commodity Code

30021010

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

Notes

Preservative Free
BSA Free

MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.

Insulinlike growth factor binding protein7, also known as mac25, a 256 aa secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulinlike growth factors (IGFs), through binding to IGFI and IGFII. IGFBP7 is widely expressed throughout normal tissues, but is also expressed in many tumor types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP7 inhibits IGFinduced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Applications

Suitable for use in FLISA and Western Blot. Other applications not tested.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

Storage and Stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

References

1. Ruan, W.J. et al. (2006) IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. J. Zhejiang, Univ. Sci. B. 7: 929932. 2. Pereira, R.C. and Canalis, E. (1999) Parathyroid hormone increases mac25/insulinlike|growth factorbinding proteinrelated protein 1 expression in cultured osteoblasts. Endocrinol. 140: 19982003.

USBio References

No references available

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I7661-17D-ML650 Insulin-like Growth Factor Binding Protein 7 (IGF Binding Protein 7, IGFBP7, IGFBP-7, IGFBP-7v, IBP-7, FSTL2, IGFBPRP1, IGFBP-rP1, MAC25 Protein, MAC25, Prostacyclin-stimulating Factor, PGI2-stimulating Factor, PSF, Tumor-derived Adhesion Factor, TAF) (MaxLight 650) CAS:

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